High-Throughput Inhalation Sample Analysis using LC-QTOF
Qmera leverages LC-QTOF instrumentation and expertise to perform sensitive (LLOQ < 1 ng/ml), high-throughput ( > 50 samples per hour) unit-dose level multi-component stability-indicating assays. This kind of assay is needed, for example, for analysis of samples generated by particle size distribution characterization experiments (NGI) during the development of the combination inhalation drug products (Triple Therapy Inhaler Options). The highly selective detection method (QTOF in SIM mode) allows for “ballistic” gradient (1 min) elution profiles, which in turn enable a fast and simple collection protocol, supporting more than 10 NGI experiments per analyst per day. This phenomenal throughput (400 samples/night on a single instrument) is 5-10 times faster than LC-UV, unlocking the evaluation of many more formulation candidates with the same budget.
Advantages of LC-QTOF
Stability-indicating by use of high selective detection
1-minute assay for combination products
LLOQ < 1 ng/ml for unit-dose level NGI
High throughput - analysis of more than 400 samples overnight
Simple and fast sample collection -> 10 NGI experiments per analyst per day
Completely automated sample submission and report generation using Qmera’s eSystems ELN is used to support the fast and error-free analysis.