Bioanalytical Services

Qmera leverages our expertise in LC-High Resolution Mass Spectrometry (LC-QTOF) and advanced separation techniques (2D-LC, online SPE, column switching) to quantify large and small molecules in biological matrices. Qmera’s instrumentation advantage offers faster turn-around and more accurate results versus competing methods (LBA, TQMS).

Large Molecule Bioanalysis

Bioassay of antibodies, bispecific antibodies, recombinant proteins, biosimilars, fusion proteins, antibody-drug conjugates (ADC), PEGylated proteins.

  • Surrogate peptides and native proteins

  • assay method development, method transfer, method qualification, method validation

  • pre-clinical pharmacokinetics (PK) sample analysis

  • fit-for-purpose non-GLP sample analysis

Advantages of LC-HRMS vs LBA

  • Rapid development - Not relying on the development of high-quality, assay-specific monoclonal antibody reagents

  • Added selectivity - helps to bypass immunoassay interference issues

  • Distinguish between closely related species- control potential biotransformation

  • Assay several proteins within a single analysis without the need for assay-specific antibodies for each analyte.

LC-QTOF proteins and small molecules bioanalytics

Small Molecule Bioanalysis

Known drugs, new chemical entities (NCE), peptides, PEGylated peptides, oligonucleotides

  • assay method development, method transfer, method qualification, method validation

  • fit-for-purpose non-GLP sample analysis

  • pre-clinical pharmacokinetics (PK) sample analysis

Advantages of LC-HRMS vs TQMS

  • Unprecedented selectivity — simplified sample prep leading to faster method development and robust assays

  • Higher signal-to-noise ratio — generation of more precise data

  • Improved sensitivity via aggregation of several product ions

  • Full scan data and post-run re-analysis enable faster MS optimization and enhanced troubleshooting ability